Motif ID: RXR{A,B,G}.p2

Z-value: 1.642


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_331684480.492.8e-14Click!
RXRGchr1_-_1654144990.152.3e-02Click!
RXRAchr9_+_1372183130.092.0e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_70288155 26.298 NM_013346
 SNX12
sorting nexin 12
chr1_+_6845381 22.955 NM_001195563
NM_001242701
NM_015215
 CAMTA1


calmodulin binding transcription activator 1


chr17_-_62833225 21.723 PLEKHM1P
pleckstrin homology domain containing, family M (with RUN domain) member 1 pseudogene
chr19_-_1174257 21.269 SBNO2
strawberry notch homolog 2 (Drosophila)
chr14_-_103988829 20.713 CKB
creatine kinase, brain
chr18_-_51750460 18.719 MBD2
methyl-CpG binding domain protein 2
chr8_-_70983549 18.702 NM_024504
 PRDM14
PR domain containing 14
chr2_+_230787195 17.197 NM_174899
 FBXO36
F-box protein 36
chr14_+_101193275 16.628 DLK1
delta-like 1 homolog (Drosophila)
chr22_+_19701968 16.386 NM_002688
 SEPT5
septin 5
chr8_-_70983468 15.633 PRDM14
PR domain containing 14
chr15_+_62682682 15.304 TLN2
talin 2
chr17_-_27278324 15.213 PHF12
PHD finger protein 12
chr14_-_103989195 14.973 NM_001823
 CKB
creatine kinase, brain
chr17_-_15902907 14.908 NM_001042697
NM_001042698
 ZSWIM7

zinc finger, SWIM-type containing 7

chr19_-_36246411 14.403 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr22_-_44258210 14.246 NM_014351
 SULT4A1
sulfotransferase family 4A, member 1
chrX_-_51239426 14.241 NM_018159
 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr19_-_1174263 14.180 NM_014963
 SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_-_14228560 14.143 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 177 entries
enrichment   p-value GO term description
5.99 2.61e-02 GO:0051893 regulation of focal adhesion assembly
5.99 2.61e-02 GO:0090109 regulation of cell-substrate junction assembly
3.25 2.07e-02 GO:0001649 osteoblast differentiation
3.21 4.02e-03 GO:0010810 regulation of cell-substrate adhesion
2.99 2.39e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.78 1.81e-02 GO:2000027 regulation of organ morphogenesis
2.76 6.62e-06 GO:0001503 ossification
2.58 3.64e-03 GO:0035107 appendage morphogenesis
2.58 3.64e-03 GO:0035108 limb morphogenesis
2.58 8.39e-03 GO:0030198 extracellular matrix organization
2.57 2.68e-03 GO:0048736 appendage development
2.57 2.68e-03 GO:0060173 limb development
2.57 1.43e-02 GO:0051216 cartilage development
2.54 3.34e-03 GO:0072001 renal system development
2.52 3.02e-02 GO:0030326 embryonic limb morphogenesis
2.52 3.02e-02 GO:0035113 embryonic appendage morphogenesis
2.50 1.35e-04 GO:0001655 urogenital system development
2.50 3.74e-02 GO:0040013 negative regulation of locomotion
2.47 1.46e-02 GO:0001822 kidney development
2.40 1.45e-03 GO:0050678 regulation of epithelial cell proliferation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
3.24 3.76e-02 GO:0005581 collagen
2.70 7.43e-03 GO:0005604 basement membrane
2.31 6.04e-03 GO:0044420 extracellular matrix part
2.12 2.59e-03 GO:0030136 clathrin-coated vesicle
1.96 5.44e-03 GO:0030135 coated vesicle
1.96 1.43e-02 GO:0031252 cell leading edge
1.90 3.37e-06 GO:0045202 synapse
1.81 8.68e-05 GO:0043005 neuron projection
1.79 2.97e-04 GO:0031012 extracellular matrix
1.73 8.76e-03 GO:0005578 proteinaceous extracellular matrix
1.72 2.19e-02 GO:0044456 synapse part
1.63 3.70e-02 GO:0048471 perinuclear region of cytoplasm
1.46 3.60e-03 GO:0005626 insoluble fraction
1.44 5.01e-05 GO:0031226 intrinsic to plasma membrane
1.44 1.33e-02 GO:0031982 vesicle
1.44 1.92e-02 GO:0031988 membrane-bounded vesicle
1.43 1.32e-04 GO:0005887 integral to plasma membrane
1.43 8.03e-03 GO:0042995 cell projection
1.43 1.92e-02 GO:0031410 cytoplasmic vesicle
1.43 3.45e-02 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
5.72 3.90e-02 GO:0048185 activin binding
3.19 1.23e-02 GO:0046332 SMAD binding
3.17 4.10e-03 GO:0003707 steroid hormone receptor activity
3.16 2.37e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.92 2.27e-04 GO:0005201 extracellular matrix structural constituent
2.43 7.47e-03 GO:0005057 receptor signaling protein activity
2.37 3.51e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.09 8.29e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.96 7.84e-03 GO:0000975 regulatory region DNA binding
1.96 7.84e-03 GO:0001067 regulatory region nucleic acid binding
1.96 7.84e-03 GO:0044212 transcription regulatory region DNA binding
1.90 3.28e-02 GO:0010843 promoter binding
1.81 2.20e-03 GO:0016563 transcription activator activity
1.76 1.02e-07 GO:0043565 sequence-specific DNA binding
1.73 2.78e-02 GO:0005083 small GTPase regulator activity
1.71 3.20e-02 GO:0016564 transcription repressor activity
1.68 1.42e-09 GO:0001071 nucleic acid binding transcription factor activity
1.68 1.42e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.60 4.41e-02 GO:0022838 substrate-specific channel activity
1.60 4.82e-02 GO:0005216 ion channel activity